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December 22, 2025
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2026: Healthcare’s pivotal year for AI transformation

Notable’s Chief Medical Officer, Dr. Aaron Neinstein, shares his forward-looking perspective on how 2026 will be a defining year for healthcare AI, bringing disruption, transformation, and a renewed focus on human connection.

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Dr. Aaron Neinstein
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As someone who has spent decades at the intersection of clinical care, technology, and innovation, I believe 2026 will mark a turning point for healthcare. 

We’ve moved from asking “Could AI help?” to realizing it already is, in dramatic ways. But as the AI hype settles, it’s clear this next phase won’t just be about technology. It will be about strategy, leadership, trust, and execution. 

Here’s what I see coming for the industry in the year ahead.

1. 2026 will be a year of reckoning and recalibration 

It will bring healthcare’s first public outcry moment with AI, a highly visible failure or incident that triggers public fear and demands for a pullback. We will hit a trough of disillusionment as some early AI deployments fail to deliver promised ROI. Organizations that bought AI based on benchmarks will learn that local deployment context matters. Some health systems will use AI governance as a strategic asset, others as compliance theater. 

2. It will bring major workforce changes 

Employees will choose jobs based on AI access; companies that block LLMs will see retention challenges. Managers will spend equal time building, monitoring, and supervising AI Agents as they do human staff. Front-line workers with configurable, EHR-integrated AI tools will spark rapid innovation. 

3. Abundance will become measurable 

Systems will move from sampling five charts per provider to reviewing every chart, continuously. Instead of outreach to the top 10% of high-risk patients, outreach will become every patient, in every language, at any time of day.

4. ROI will flip to 10x value creation from efficiency gains 

Chart reviews will shift from periodic sampling to AI reviewing every chart in real time; every patient will reliably receive tailored pre-procedure education and post-discharge check-ins; the burden of faxes will disappear as ingestion, sorting, and transcription become fully automated. 

5. AI-first practices will reshape care delivery 

New practices will be built from scratch around AI Agents to support panel sizes three to five times larger at equal or higher quality and dramatically lower cost. Human connection will take center stage again; AI will handle pattern analysis and routine adjustments, so clinicians can shift from memorizing facts to focusing on meaning – gaining the time and capacity to ask questions like “How does your illness affect your life?” Because of this, nurses, MAs, and care coordinators will move up the value chain, as they can spend more time on empathy, clinical judgement, and complex situations rather than administrative tasks. 

6. The patient experience will change for the better 

Many patients will prefer to speak to AI; it’s faster, available 24/7, and multilingual, making traditional IVR phone trees obsolete. AI-driven tailoring through language, literacy, and communication preferences will shift healthcare from “everyone gets the same” to “everyone gets what they need.” Concierge-level service will become the default expectation, and things like daily check-ins, proactive alerts, and real-time education will move from luxury to standard. AI will expand access for underserved groups, as patients with limited proficiency in English will get frictionless, native-language access via conversational AI. 

A transformative opportunity

2026 won’t be a quiet year. It will test us. But it will also be the year we break through old paradigms and create the space for real human care to thrive again. 

For those ready to lead, adapt, and think differently, the opportunity ahead is transformative. 

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